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KMID : 0385520160290040179
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Analytical Science & Technology
2016 Volume.29 No. 4 p.179 ~ p.185
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Simultaneous analysis of β-lactam antibiotics and β-blockers by LC-MS/MS
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Son Bo-young
Kim Jun-il
An Chi-hwa
Lee Su-won
Kim Bog-Soon
Chung Deuk-mo
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Abstract
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An effective analytical method has been developed for the determination of β-blockers(atenolol,metoprolol and propranolol) and 6 β-lactams(amoxicillin, penicillin G, cefaclor, cefadroxil, cephalexin and cephradine) in water samples using two different cartridges. The samples were extracted by solid-phase extraction (SPE) with the usage of polymeric hydrophile-lipophile balance(HLB cartridges) and strong cation-exchange mixed-mode polymeric sorbent (MCX cartridges). A XDB-C18 column(1.8 μm; 3.0 mm × 100 mm) was used for the sufficient chromatographic resolution. The calibration curves showed good linearity with high correlation coefficients (>0.995). The method detection limits (MDL) and the limits of quantification(LOQ) were from 1.1 to 3.9 ng/L and from 5 to 13 ng/L, respectively. The method was applied for the determination of the target compounds in tributaries and raw water of the Han River and these were found at N.D. to 0.209 μg/L.
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KEYWORD
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β-blockers, β-lactams antibiotics, SPE, LC-MS/MS,
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